THIAZOLIDIN-4-ONE DERIVATIVES AND ACID ADDITION SALTS THEREOF

• Main Authors: MIZUTANI, MASATO, MOROOKA, SHIGEAKI, AONO, SHUNJI, KOMURO, YOSHIHIRO, KOJIMA, ATSUYUKI, TANABE, YOU, ENOMOTO, MASAO, SANEMITSU, YUZURU
• Format: Patent
• Language: English; French
• Published: 27.02.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Thiazolidin-4-one derivative represented by the following general formula (I) and acid addition salts thereof (I) wherein; R1 and R2 are the same or different and denote each (i) a residue represented by the general formula -A-R4 wherein, A denotes a single bond, C1-C8 alkylene, C2-C8 alkenylene, or C2-C8 alkynylene and R4 denotes hydrogen, C1-C12 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl, or C1-C6 haloalkyl, or (ii) a residue represented by the general formula wherein, B denotes a single bond or C1-C6 alkylene, R5 denotes hydrogen, C1-C6 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl, substituted silyl, or substituted or unsubstituted aryl, n and n' denote each an integer of 2 to 4, m denotes an integer of 1 to 3, and m' denotes an integer of 0 to 2; and R3 denotes hydrogen, C1-C2 alkyl, allyl, 2propynyl, or a residue represented by (a) the general formula (CH2)? R6 wherein, R6 denotes halogen, an aryl group substituted or unsubstituted by one or more hydroxy or C1-C4 alkoxy groups, or a residue represented by the general formula -D-R7 (D denotes oxygen or sulfur and R7 denotes hydrogen, C1-C4 alkyl, or C1-C4 alkanol) and ? denotes an integer of 2 to 4, (b) the general formula ?CH2? CO-E-R8 wherein, E denotes oxygen, sulfur, imino, or C1-C4 alkylimino, R8 denotes hydrogen or C1-C4 alkyl, or -(E-R8) denotes a 5- to 7-membered cyclic amino group which optionally contains other hetero atoms, and k denotes an integer of 1 to 3, or (c) the general formula - F-R9 wherein, F denotes C2-C6 alkylene and R9 denotes a nitrogen-containing heterocyclic aromatic residue or an amino group represented by the general formula (R10 denotes hydrogen, C1-C4 alkyl, or C1-C4 alkyl or R10 in combination with R11 denotes a 5- to