ANTI-TUMOR METHOD AND COMPOUNDS

This invention provides anti-cancer compounds of the formula I wherein A is -S(O)n-, -CH2S(O)n-, -N(ethyl)-, or -CH2-; D is -CH2-, -S(O)n-, -NR-, or -CH2S(O)n-; B is -CH2-, -O-, -S(O)n-, or -NR-; R is methyl or ethyl; R1 is hydrogen or halo; R2 is halo or trifluoromethyl; n is 0-2; provided that: B...

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Bibliographic Details
Main Authors TAO, EDDIE V, RIEDER, BRENT J, HOWBERT, JAMES J, HARPER, RICHARD W, POORE, GERALD A
Format Patent
LanguageEnglish
French
Published 16.08.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides anti-cancer compounds of the formula I wherein A is -S(O)n-, -CH2S(O)n-, -N(ethyl)-, or -CH2-; D is -CH2-, -S(O)n-, -NR-, or -CH2S(O)n-; B is -CH2-, -O-, -S(O)n-, or -NR-; R is methyl or ethyl; R1 is hydrogen or halo; R2 is halo or trifluoromethyl; n is 0-2; provided that: B is a group other than -CH2- only when A and D are both -CH2-; D is -CH2S(O)n- only when A is -S(O)n-, -N(ethyl)- or -CH2-; and no more than two of A, B and D are -CH2-; provided that neither A nor D can be -S(O)-unless either B or the other of A and D is a group other than -CH2-.
Bibliography:Application Number: CA19880566099