(1)-1BETA-ETHYL-1ALPHA-HYDROXYMETHYL-1,2,3,4,6,7,12,12-BETA ALPHA-OCTAHYDROINDOLO (2,3-A) QUINOLIZINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

23305-1063 The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,12b.alpha.-octahydroindolo¢2,3-a!quinoli-zine of the formula (I) (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of th...

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Main Authors KUTHI, CSABA, LASZLOVSZKY, ISTVAN, KALAUS, GYOERGY, SZOMBATHELYI, ZSOLT, GERE, ANIKO, SZABO, LAJOS, CSOMOR, KATALIN, KISS, BELA, SZPORNY, LASZLO, KARPATI, EGON, SZANTAY, CSABA, FORGACS, LILLA, LAPIS, ERZSEBET
Format Patent
LanguageEnglish
French
Published 28.04.1992
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:23305-1063 The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,12b.alpha.-octahydroindolo¢2,3-a!quinoli-zine of the formula (I) (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.
Bibliography:Application Number: CA19860507011