7-OXABICYCLOHEPTANE SUBSTITUTED AMIDE-THIOAMIDE PROSTALGLANDIN ANALOGS

ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED AMIDE-THIOAMIDE PROSTAGLANDIN ANALOGS New 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs are cardiovascular agents useful, for example, in the treatment of thrombotic disease and have the structural formula including all stereoisomers t...

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Bibliographic Details
Main Authors NAKANE, MASAMI, REID, JOYCE A
Format Patent
LanguageEnglish
French
Published 02.07.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:ABSTRACT 7-OXABICYCLOHEPTANE SUBSTITUTED AMIDE-THIOAMIDE PROSTAGLANDIN ANALOGS New 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs are cardiovascular agents useful, for example, in the treatment of thrombotic disease and have the structural formula including all stereoisomers thereof, wherein m is 0 to 4; A is -CH=CH- or -CH2-CH2-; n is 1 to 5; Q is -CH=CH-, -CH2-, , , , or a single bond; R is-CO2H,-CO2alkyl, -CO2alkali metal, -CO2polyhydroxyamine salt, -CH2OH, , or -?NR4R5 wherein R4 and R5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R4 and R5 being other than hydroxy and lower alkoxy; p is 1 to 4; R1 is H or lower alkyl; q is 1 to 12; R2 is H or lower alkyl; and R3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy, amino, alkylamino, or arylamino.
Bibliography:Application Number: CA19860515053