PROCESS FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES USEFUL AS ANTIBIOTICS

The present invention relates to a process for the preparation of derivatives of the cephalosporin family, of formula: (I) in which : X is an oxygen atom or a sulfur atom , n is zero, 1 or 2. . R1, R2 and R3 each designate, independently a hydrogen atom or else R1 and R2 designate a hydrogen atom or...

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Bibliographic Details
Main Authors SALHI, ALI, OLLIERO, DOMINIQUE
Format Patent
LanguageEnglish
French
Published 12.03.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a process for the preparation of derivatives of the cephalosporin family, of formula: (I) in which : X is an oxygen atom or a sulfur atom , n is zero, 1 or 2. . R1, R2 and R3 each designate, independently a hydrogen atom or else R1 and R2 designate a hydrogen atom or a methyl group, and R3 designates a carboxyl or cyclopropyl group, or else . R1 and R2 taken together with the carbon atom to which they are linked form a cyclobutyl or cyclopentyl group and R3 is a carboxyl group. . B is the residue of a primary or secondary amine, said derivatives are useful in therapeutics.
Bibliography:Application Number: CA19850490887