1-CYCLOHEXYL-3,4-DIHYDROISOQUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to new l-cyclohexyl-3,4-dihydroisoquinoline derivatives of the formula (I) (I) wherein R1 and R2 each independently represents hydrogen, hydroxyl or alkoxy having from 1 to 6 carbon atoms, X is oxygen and Z is a =CH2 or =CH-COOR3 group, in which R3 is hydrogen or alkyl having f...

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Main Authors SZPORNY, LASZLO, EZER, ELEMER, LAZAR, JANOES, MOTIKA, GABOR, KOBOR, JENOE, HAJOS, GYOERGY, BERNATH, GABOR, PALOSI, EVA, DENES, LASZLO
Format Patent
LanguageEnglish
French
Published 13.02.1990
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new l-cyclohexyl-3,4-dihydroisoquinoline derivatives of the formula (I) (I) wherein R1 and R2 each independently represents hydrogen, hydroxyl or alkoxy having from 1 to 6 carbon atoms, X is oxygen and Z is a =CH2 or =CH-COOR3 group, in which R3 is hydrogen or alkyl having from 1 to 6 carbon atoms; or X represents an =NR4 group, in which R4 is hydrogen or hydroxyl, and Z is a =CH-CN, =CH2 or =CH-COOR3 group, in which R3 is as defined above, and acid addition salts thereof. The compounds of formula (I) are pharmaceutically active, in particular show antispasm, analgesic, gastric acid secretion inhibiting, sedative and hypnotic activity and effectively reduce the alcoholic narcosis time. According to a further aspect of the invention there is provided a process for the preparation of these compounds. The invention further relates to pharmaceutical compositions containing them as active ingredient.
Bibliography:Application Number: CA19850478874