TRICYCLIC OR TETRACYCLIC COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

: The present invention is directed to compounds of the formula: wherein A means an alkylene; Y-Z means , -CH-CH-, -CH2CH2-. or ; R1 and R2 are each a substituent; R3 is a hydrogen atom, alkyl, or alkoxy, R4 is phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally subst...

Full description

Saved in:
Bibliographic Details
Main Authors HATANO, NAONOBU, SATO, FUMINORI, KUROKAWA, MIKIO, UNO, HITOSHI
Format Patent
LanguageEnglish
French
Published 13.02.1990
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:: The present invention is directed to compounds of the formula: wherein A means an alkylene; Y-Z means , -CH-CH-, -CH2CH2-. or ; R1 and R2 are each a substituent; R3 is a hydrogen atom, alkyl, or alkoxy, R4 is phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, quinolyl, benzoylalkyl, benzoyl, furoyl, thenoyl, phenyloxycarbonyl, phenyloxysulfonyl, or phenylsulfonyl; a is 2 or 3, b and c are each 1 or 2, and d is an integer of 0 to 2, provided that the phenyl, phenyl moiety and naphthyl may optionally be substituted, or a pharmaceutically acceptable salt thereof, processes for the preparation thereof, and pharmaceutical compositions containing the same. The compounds and salts thereof show potent calcium antagonistic activity and are useful for the prophylaxis and treatment of hypertension and/or ischemic heart disease.
Bibliography:Application Number: CA19860500867