STEROIDS ESTERIFIED IN POSITION 17 AND THIOESTERIFIED IN POSITION 21, A PROCESS FOR PREPARING THEM AND THEIR USE AS MEDICAMENTS

• Main Authors: GROUHEL, AGNES G, TOROSSIAN, DIERAN R, AUBARD, GILBERT G, ROUX, CLAUDE P.J
• Format: Patent
• Language: English; French
• Published: 28.03.1989
• Edition: 4
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

Compounds of formula : wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen T and U, independently of each other represent hydrogen atoms or together form 2 double bond, V is a hydrogen atom or a methyl group at the ?-position, W is a hydrogen atom or a halogen atom at the ?-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z1 is a hydrogen atom, a methyl group at the ?- or .beta.-position, whilst Z2 is a hydrogen atom, or Z1 and Z2 together form a methylene group.These compounds have anti-inflammatory activity.