STEROIDS ESTERIFIED IN POSITION 17 AND THIOESTERIFIED IN POSITION 21, A PROCESS FOR PREPARING THEM AND THEIR USE AS MEDICAMENTS

Compounds of formula : wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 car...

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Main Authors GROUHEL, AGNES G, TOROSSIAN, DIERAN R, AUBARD, GILBERT G, ROUX, CLAUDE P.J
Format Patent
LanguageEnglish
French
Published 28.03.1989
Edition4
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Compounds of formula : wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen T and U, independently of each other represent hydrogen atoms or together form 2 double bond, V is a hydrogen atom or a methyl group at the ?-position, W is a hydrogen atom or a halogen atom at the ?-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z1 is a hydrogen atom, a methyl group at the ?- or .beta.-position, whilst Z2 is a hydrogen atom, or Z1 and Z2 together form a methylene group.These compounds have anti-inflammatory activity.
Bibliography:Application Number: CA19820408207