AMINO ACID DERIVATIVES, A PROCESS FOR PRODUCING THEM AND THEIR USE

• Main Authors: HOEFKE, WOLFGANG, SCHNORRENBERG, GERD, GAIDA, WOLFRAM, LOSEL, WALTER, WIEDEMANN, INGRID, ROOS, OTTO
• Format: Patent
• Language: English; French
• Published: 11.10.1988
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Amino Acid Derivatives, Process for their Preparation and Pharmaceutical Preparations Containing them The specification described new amino acids derivatives of formula (X) (I) wherein R1 represents a hydrogen atom, an alkyl group with 1 to 6 carbon atoms or a phenylalkyl group with 7 to 12 carbon atoms; R2 represents a hydrogen atom; an alkyl group with 1 to 4 carbon atoms or a phenylalkyl group with 7 to 12 carbon atoms, R3 represents a hydrogen atom or an alkyl group with 1 to 6 carbon atoms; n and m each represent 0, 1 or 2, the sum of n and m being 1 or 2; X, Y and Z each represent a group or atom selected from oxygen or sulphur atoms or NR4, CR5, CHR5, , groups, provided that only one of the radicals X, Y and Z can represent oxygen or sulphur atoms or groups and only one or two of the radicals X, Y and Z can represent an NR4 group; R4 represents a hydrogen atom or an alkyl group with 1 to 4 carbon atoms; and R5 represents a hydrogen atom or, together with a vicinal radical R5, a phenyl ring, or in the case when both m and n = 1, the dihydro form with its double bond in conjunction to the Cterminal carboxyl group, and their salts. a process for producing them, pharmaceutical compositions containing one or more compounds of general formula I as active substance, and their use in pharmaceuticals. The new amino acid derivatives have a longlasting hypotensive effect which is based on an inhibition of the angiotensin I-converting enzyme.