10- AND 11- SUBSTITUTED APOVINCAMINOL COMPOUNDS AND ESTERS THEREOF WITH 3,4,5-TRIMETROXY BENZOIC AND PROCESS FOR PRODUCING THEM

• Main Authors: ZAJER, MARIA, SZPORNY, LASZLO, KARPATI, EGON, SZANTAY, CSABA, KIRALY, GYOENGYVER, FORGACH, LILLA, KALAUS, GYOERGY, ROSDY, BELA, SZABO, LAJOS, KIRALY, ARPAD
• Format: Patent
• Language: English; French
• Published: 21.01.1986
• Edition: 4
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to new polycyclic compounds substituted on the A-ring. More particularly, the invention concerns new polycyclic compounds of the general formula /I/ < IMG > /I/ wherein R1 is methoxy or halogen and R2 is hydrogen; or R1 is hydrogen and R2 is halogen and acid addition salts thereof. According to another aspect of the invention the new compounds of the general formula /I/ are prepared by reacting compounds of the general formula /II/ < IMG > /II/ wherein R1 and R2 are as defined above, with 3,4,5 -trimethoxy-benzoic acid or a derivative thereof capable of acylation. According to still another aspect of the invention there are provided pharmaceutical compositions comprising as an active ingredient a compound of the general formula /1/. The compounds have phosphodiesterase inhibiting activity.