3,4-DIHYDRO-5H-2,3-BENZODIAZEPINE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF

The invention relates to new 3,4-dihydro- -5H-2,3-benzodiazepine derivatives of the general formula (I) and pharmaceutically acceptable acid addition salts thereof. wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy,...

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Main Authors ANDRASI, FERENC, BALOGH, TIBOR, MORAVCSIK, IMRE, KOEROESI, JENOE, LANG, TIBOR, ILA, LAJOS, SZEKELY, JOZSEF, GOLDSCHMIDT, KATALIN NEE HORVATH, SINEGER, ELEONORA, HAMORI, TAMAS
Format Patent
LanguageEnglish
French
Published 27.11.1984
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new 3,4-dihydro- -5H-2,3-benzodiazepine derivatives of the general formula (I) and pharmaceutically acceptable acid addition salts thereof. wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C1-4 alkoxy and benzyloxy; a furyl or a thienyl group, R1 stands for a hydrogen atom or a C1-4 alkyl group, R2 and R3 each represent hydrogen atom, C1-4 alkoxy, C4-7 cycloalkoxy or benzyloxy group. The new compounds of the general formula (I) can be prepared by reducing a 5H-2,3-benodiazepine derivative of the general formula (II) (II) wherein R, R1, R2 and R3 have the above-defined meanings, with an inorganic or organic hydride and and complex metal hydride. The new compounds of the general formula (I) possess significant central nervous effects and can advantageously be used in the therapy.
Bibliography:Application Number: CA19820398115