2-CYCLIC AMINO-2-(1,2-BENZISOXAZOL-3-YL)-ACETIC ACID ESTER DERIVATIVES

The invention provides novel 2-cyclic amino-2-(1, 2-benzisoxazol-3-yl) acetic acid derivatives of the formula: (I) wherein R1 is hydrogen or a halogen atom, R2 is a lower alkyl group, Am is a 5- to 9-membered saturated cyclic amino group which may be substituted by a lower alkyl group, and the group...

Full description

Saved in:
Bibliographic Details
Main Authors KAWASHIMA, KATSUYOSHI, NISHIMURA, HARUKI, NARUTO, SHUNSUKE, MIZUTA, HIROYUKI, KADOKAWA, TOSHIAKI
Format Patent
LanguageEnglish
French
Published 25.09.1984
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
LAND VEHICLES FOR TRAVELLING OTHERWISE THAN ON RAILS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MOTOR VEHICLES
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TRAILERS
TRANSPORTING
VEHICLE SUSPENSION ARRANGEMENTS
VEHICLES IN GENERAL
Online AccessGet full text

Cover

More Information
Summary:The invention provides novel 2-cyclic amino-2-(1, 2-benzisoxazol-3-yl) acetic acid derivatives of the formula: (I) wherein R1 is hydrogen or a halogen atom, R2 is a lower alkyl group, Am is a 5- to 9-membered saturated cyclic amino group which may be substituted by a lower alkyl group, and the group: binds to the piperidine moiety at 3- or 4-position of the latter; and their pharmaceutically acceptable acid addition salts and quaternary ammonium salts. The invention also provides a process for their preparation, and pharmaceutical compositions containing these compounds. They have potent anticholinergic antispasmodic activity, while they are weak in side effects such as mydriasis, inhibition of salivary secretion and tachycardia.
Bibliography:Application Number: CA19820410220