MORPHOLINES

Morpholine derivatives of the formula (I) and their acid addition salts, wherein n represents 1,2 or 3, R4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-tetrahydrofuryl-methyl or cyclo(lower)alkylmethyl, and (i) R1 is hydrogen, R2 is and R3 is alkyl of 1 to 10 carbon at...

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Bibliographic Details
Main Authors BRADLEY, GERALD, WHITE, ALAN C
Format Patent
LanguageEnglish
French
Published 31.07.1984
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Morpholine derivatives of the formula (I) and their acid addition salts, wherein n represents 1,2 or 3, R4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl(lower)alkyl, 2-tetrahydrofuryl-methyl or cyclo(lower)alkylmethyl, and (i) R1 is hydrogen, R2 is and R3 is alkyl of 1 to 10 carbon atoms, or (ii) R1 is and R2 and R3 are each hydrogen or alkyl of 1 to 10 carbon atoms (wherein OR5 is hydroxy, acyloxy or a protected hydroxy group) possess analgesic and/or opiate antagonistic activity or are useful as intermediates for other compounds of formula I possessing such activity.
Bibliography:Application Number: CA19820397655