PROCESS FOR THE PREPARATION OF BIS-INDOLE-ALKALOIDS AND ACID ADDITION SALTS THEREOF AND NEW BIS-INDOLE-ALKALOIDS

The invention relates to the oxidation of vincristine or leurosine or acid addition salts of vincristine or leurosine by means of chromic acid or alkali metal dichromates under specified conditions. Oxidation of vinblastine or its acid addition salts yields N-desmethyl-vinblastine and vincristine an...

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Main Authors JOVANOVICS, KAROLINA, (NEE NAGY), HINDI, IVAN, GOEROEG, SANDOR, SUGAR, JANOS, ECKHARDT, SANDOR, RELLE, ZSUZSANNA, (NEE SOMFAI), FARKAS, ELEK
Format Patent
LanguageEnglish
French
Published 15.03.1983
Edition3
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention relates to the oxidation of vincristine or leurosine or acid addition salts of vincristine or leurosine by means of chromic acid or alkali metal dichromates under specified conditions. Oxidation of vinblastine or its acid addition salts yields N-desmethyl-vinblastine and vincristine and also a new compound designated "RGH-4451", Oxidation of leurosine or its acid addition salts yields N-desmethyl leurosine, Ndesmethyl-N-formyl leurosine and a new compound designated "RGH-4478" These oxidation products display anti-tumor properties or are readily convertible to compounds displaying anti-tumor properties.
AbstractList The invention relates to the oxidation of vincristine or leurosine or acid addition salts of vincristine or leurosine by means of chromic acid or alkali metal dichromates under specified conditions. Oxidation of vinblastine or its acid addition salts yields N-desmethyl-vinblastine and vincristine and also a new compound designated "RGH-4451", Oxidation of leurosine or its acid addition salts yields N-desmethyl leurosine, Ndesmethyl-N-formyl leurosine and a new compound designated "RGH-4478" These oxidation products display anti-tumor properties or are readily convertible to compounds displaying anti-tumor properties.
Author SUGAR, JANOS
GOEROEG, SANDOR
FARKAS, ELEK
RELLE, ZSUZSANNA, (NEE SOMFAI)
ECKHARDT, SANDOR
JOVANOVICS, KAROLINA, (NEE NAGY)
HINDI, IVAN
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– fullname: RELLE, ZSUZSANNA, (NEE SOMFAI)
– fullname: FARKAS, ELEK
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DocumentTitleAlternate METHODE DE PREPARATION DE BIS-INDOLE-ALCALOIDES; LEURS SELS D'ADDITION ACIDE, ET NOUVEAUX BIS-INDOLE-ALCALOIDES
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Snippet The invention relates to the oxidation of vincristine or leurosine or acid addition salts of vincristine or leurosine by means of chromic acid or alkali metal...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title PROCESS FOR THE PREPARATION OF BIS-INDOLE-ALKALOIDS AND ACID ADDITION SALTS THEREOF AND NEW BIS-INDOLE-ALKALOIDS
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