PROCESS FOR PREPARING 10-HALOGEN-E-HOMO EBURNANES

The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), (I) wherein R2 is a C1-6 alkyl group and X is halogen, and epimers, optically active derivatives and pharmaceutically acceptable acid addition salts thereof. These substances exert vasodilating effects and ca...

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Bibliographic Details
Main Authors SZANTAY, CSABA, DREXLER, FERENC, KALAUS, GYOERGY, KAVE, TIBOR, SZABO, LAJOS, DANCSI, LAJOS
Format Patent
LanguageEnglish
French
Published 25.01.1983
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), (I) wherein R2 is a C1-6 alkyl group and X is halogen, and epimers, optically active derivatives and pharmaceutically acceptable acid addition salts thereof. These substances exert vasodilating effects and can be applied to advantage in the therapy. The new compounds are prepared so that a racemic or optically active 9-halo-octahydroindoloquinolisine derivative of the general formula (II), (II) wherein R2 and X are as defined above and R1 is a C1-6 alkyl group, or an acid addition salt thereof is treated with a strong base, and, if desired, the 15epimers of the resulting compound having the general formula (I) are separated from each other, and/or, if desired, the resulting substance is converted into its pharmaceutically acceptable acid addition salt and/or resolved.
Bibliography:Application Number: CA19800358098