PROCESS FOR PREPARATION OF 3-HALOMETHYLCEPHEMS

3-Halomethyl-3-cephems are provided by a novel process comprising reacting a 3-methylenecepham with an alkali metal salt of a lower alcohol or a bicyclic amidine base in the presence of a positive halogenating agent at a temperature ranging from -80.degree.C. to 20.degree.C. The 3-halomethyl-cephems...

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Bibliographic Details
Main Author KOPPEL, GARY A
Format Patent
LanguageEnglish
French
Published 13.01.1981
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:3-Halomethyl-3-cephems are provided by a novel process comprising reacting a 3-methylenecepham with an alkali metal salt of a lower alcohol or a bicyclic amidine base in the presence of a positive halogenating agent at a temperature ranging from -80.degree.C. to 20.degree.C. The 3-halomethyl-cephems provided by this invention are useful intermediates for the preparation of known cephalosporin antibiotics. X-4586
Bibliography:Application Number: CA19770271434