SULFONAMIDO-BENZOIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

• Main Authors: HUSZTI, ZSUZSA, KOSARY, JUDIT, CSEH, GYOERGY, SZILAGYI, VERONIKA (NEE PAP), KASZTREINER, ENDRE, STVERTECZKY, JUDIT (NEE SZTROKAY), KENESSEY, AGNES
• Format: Patent
• Language: English; French
• Published: 23.12.1980
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention related to novel sulfonamidobenzoic acid derivatives having the general formula wherein R1 denotes a C1-4 alkoxy group or a hydrazino group or an NR4R5 groups wherein R4 and R5 denote each a hydrogen atom or an identical or different C1-4 alkyl group; furthermore R4 may denote an aralkyl or substituted aralkyl group provided that R5 denotes a hydrogen atom; furthermore NR4R5 may denote a morpholine or piperazine ring; R2 and R3 may denote each a hydrogen atom or an identical or different C1-4 aliphatic group; furthermore R2 may denote a cycloaliphatic, aralkyl, substituted aralkyl or amino group provided that R3 denotes a hydrogen atom; furthermore R2 and R3 may denote together with the adjacent nitrogen atom a morpholino ring, an unsubstituted piperazine ring or a substituted piperazine ring, and to their pharmaceutically acceptable acid addition salts. Furthermore, the invention related to a process for preparing these compounds. The novel sulfonamidobenzoic acid derivatives having the general formula I possess significant tyrozine-paralyzing activity and thus they retard the biosynthesis of noradrenaline.