PREPARATION OF 7-METHYL-4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE DERIVATIVES

New 1,6-naphthyridine derivatives of the formula (I) (I) useful as intermediates in preparing antibacterial agents. In the compounds R3 is hydrogen or C1-6 alkyl; Y is a tertiary nitrogen-containing aromatic, heterocyclic ring attached through the nitrogen atom, or a trialkyl-amino group and Z is an...

Full description

Saved in:
Bibliographic Details
Main Authors VASVARI, LELLE, RITLI, PETER, HORVATH, AGNES, HERMECZ, ISTVAN, MESZAROS, ZOLTAN, MANDI, ATTILA
Format Patent
LanguageEnglish
French
Published 12.12.1978
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:New 1,6-naphthyridine derivatives of the formula (I) (I) useful as intermediates in preparing antibacterial agents. In the compounds R3 is hydrogen or C1-6 alkyl; Y is a tertiary nitrogen-containing aromatic, heterocyclic ring attached through the nitrogen atom, or a trialkyl-amino group and Z is an anion. The process is selected froma) Reacting a compound of the formula (III) (III) wherein the N-alkyl-group has 1-6 carbon atoms) with an aromatic tertiary base, or a trialkylamine, in the presence of a halogen,b) Reacting a compound of the formula (II) (II) wherein alkyl is as stated above, and X stands for halogen with a tertiary base; andc) Reacting the compound of the formula (IV) (IV) in the presence of a halogen with an aromatic tertiary base, or a trialkylamine, and, if desired, alkylating the compound of the formula (I) thus obtained(wherein R3 is hydrogen). If desired, the halide thus obtained may be converted into an other halide or an other pharmaceutically acceptable anion.
Bibliography:Application Number: CA19740216999