BENZOXAZOLE DERIVATIVES
Novel benzoxazole derivatives of formula I I wherein the group -CR1R2R3 is in the 5- or 6- position of the benzoxazole nucleus, R4 is a phenyl group optionally substituted in any position by one or more C1-6 alkylsulphonyl, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, C2-7 acyl, hydroxy,...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
21.11.1978
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Subjects | |
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Abstract | Novel benzoxazole derivatives of formula I I wherein the group -CR1R2R3 is in the 5- or 6- position of the benzoxazole nucleus, R4 is a phenyl group optionally substituted in any position by one or more C1-6 alkylsulphonyl, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, C2-7 acyl, hydroxy, amino, C1-6 alkylamino or C2-7 acylamino groups or optionally substituted in two adjacent positions by methyleneor ethylene-dioxy, R1 is hydrogen or C1-6 alkyl, R2 is hydrogen and R3 is a nitrile or carboxy group, or a salt, ester, amide or hydroxamic acid derivative thereof, are described. Also described is a process for preparing such compounds, comprising reducing a compound of formula I above wherein R1, R3 and R4 are as defined above, and R2 is halogen, hydroxy or C2-7 acyloxy. These compounds possess analgesic, antipyretic and/or anti-inflammatory activity, or are useful an intermediates for the preparation of compounds which do have such activity. |
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AbstractList | Novel benzoxazole derivatives of formula I I wherein the group -CR1R2R3 is in the 5- or 6- position of the benzoxazole nucleus, R4 is a phenyl group optionally substituted in any position by one or more C1-6 alkylsulphonyl, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, C2-7 acyl, hydroxy, amino, C1-6 alkylamino or C2-7 acylamino groups or optionally substituted in two adjacent positions by methyleneor ethylene-dioxy, R1 is hydrogen or C1-6 alkyl, R2 is hydrogen and R3 is a nitrile or carboxy group, or a salt, ester, amide or hydroxamic acid derivative thereof, are described. Also described is a process for preparing such compounds, comprising reducing a compound of formula I above wherein R1, R3 and R4 are as defined above, and R2 is halogen, hydroxy or C2-7 acyloxy. These compounds possess analgesic, antipyretic and/or anti-inflammatory activity, or are useful an intermediates for the preparation of compounds which do have such activity. |
Author | HICKS, TERENCE A EVANS, DELME DUNWELL, DAVID W |
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DocumentTitleAlternate | DERIVES DE BENZOXAZOLE |
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Notes | Application Number: CA19740211959 |
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Snippet | Novel benzoxazole derivatives of formula I I wherein the group -CR1R2R3 is in the 5- or 6- position of the benzoxazole nucleus, R4 is a phenyl group optionally... |
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Title | BENZOXAZOLE DERIVATIVES |
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