2,5 OR 2,6 DISUBSTITUTED BENZOXAZOLES

A compound of formula II: (II) where the group is in the 5- or 6-position of the benzoxazole nucleus, A is -CH2-, -CO-, , -NH or NCH3-; R4 is a phenyl group, R2 is hydrogen or methyl, and R3 is the group -COOR5, where R5 is C1-4 alkyl, or the group -COOH or an alkali or alkaline earth metal, alumini...

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Bibliographic Details
Main Authors DUNWELL, DAVID W, EVANS, DELME, HICKS, TERENCE A
Format Patent
LanguageEnglish
French
Published 12.09.1978
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A compound of formula II: (II) where the group is in the 5- or 6-position of the benzoxazole nucleus, A is -CH2-, -CO-, , -NH or NCH3-; R4 is a phenyl group, R2 is hydrogen or methyl, and R3 is the group -COOR5, where R5 is C1-4 alkyl, or the group -COOH or an alkali or alkaline earth metal, aluminium or ammonium salt thereof. The phenyl group may be substituted by one or two groups selected from the group consisting of halogen, trifluoromethyl, methyl, methoxy, acetyl and methylsulphonyl. The specification also discloses a process for preparing the above compound. The above compound has valuable pharmacological activities such as analgestic, antipyretic and/or antiinflammatory activities.
Bibliography:Application Number: CA19740212029