3-(2-AMINOPROPYL)-INDOLES

Pharmacologically valuable 3-(aminopropyl)-indoles have the general formula IN WHICH R1 is phenyl, halophenyl, nitrophenyl, aminophenyl, loweralkoxyphenyl or pyridyl, R2 is hydrogen or methyl, R3 and R4 are each hydrogen or lower alkyl or taken together form a polymethylene group which may be interr...

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Bibliographic Details
Main Author DEMARNE, HENRI
Format Patent
LanguageEnglish
Published 11.01.1977
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Pharmacologically valuable 3-(aminopropyl)-indoles have the general formula IN WHICH R1 is phenyl, halophenyl, nitrophenyl, aminophenyl, loweralkoxyphenyl or pyridyl, R2 is hydrogen or methyl, R3 and R4 are each hydrogen or lower alkyl or taken together form a polymethylene group which may be interrupted by oxygen so that -NR3R4 is a heteromonocycle having 5 or 6 nuclear atoms and R5 is hydrogen, fluorine, chlorine or methoxy. Especially interesting are those compounds in which at least one of R1 and R5 comprises a flourine atom and -NR3R4 is pyrrolidino. The compounds are made by condensation of correspondingly substituted indolylacetones with amines HNR3R4 in a reducing medium or, in certain cases, by reduction of correspondingly substituted indolylacetoximes with or without subsequent lower alkylation.
Bibliography:Application Number: CA19730162180