anticorpos contra fator de crescimento de nervo (ngf) com estabilidade in vivo intensificada
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-...
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Main Authors | , , , , , , |
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Format | Patent |
Language | Portuguese |
Published |
09.01.2018
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided. |
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Bibliography: | Application Number: BR2010PI14445 |