derivado de triazina e composição farmacêutica compreendendo o mesmo

• Main Authors: MIHO OOHARA, TAKAYUKI KAMEYAMA, TAKESHI ENDOH, TSUYOSHI HASEGAWA, YUKIO TADA, HIROYUKI KAI
• Format: Patent
• Language: Portuguese
• Published: 19.04.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a novel P2X 3 and/or P2X 2 / 3 receptor antago nist. A compound represented by the formula (I): wherein R a , R b and R c are, (a) R a and R b are taken together =Z; and R c is a group represented by R 1c ; or (b) R b and R c are taken together to form a bond; and R a is a group represented by -Y-R 1a ; R 1a and R 1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R 2 and R 3 are each independently substituted or unsubstituted aryl, etc.; R 4a and R 4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is -N(R 5 )-, etc.; R 5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; -Y- is -O-, etc.; =Z is =O, etc.; and n is an integer of 0 to 4.