composto 2,4-diaminopirimidina

[Problem] Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKC¸ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. [Means for Solution] The present inventors have conducted extensive...

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Main Authors KOICHIRO MUKOYOSHI, SHIGEKI KUNIKAWA, JUN MAEDA, AKIRA TANAKA, YUJI TAKASUNA, SHINYA NAGASHIMA, NOBORU CHIDA
Format Patent
LanguagePortuguese
Published 01.12.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:[Problem] Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKC¸ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. [Means for Solution] The present inventors have conducted extensive studies on a compound having a PKC¸ inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKC¸ inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKC¸ inhibitor or an inhibitor of acute rejection occurring in transplantation.
Bibliography:Application Number: BR2009PI18472