processo para a preparação de uma mistura, e, uso dos compostos

Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (...

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Bibliographic Details
Main Authors ANDREAS LINDENMAIER, ACHIM BÜHRER, GERHARD BECK, MARTIN VOGT
Format Patent
LanguagePortuguese
Published 17.11.2015
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or -NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.
Bibliography:Application Number: BR2009PI17962