composto, composição farmacêutica, e, métodos para tratar dor, para tratar um distúrbio ou uma doença, e para fabricar um co-cristal

The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine h...

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Bibliographic Details
Main Authors REX A. SHIPPLETT, JEFFREY S. STULTS, G. PATRICK STAHLY, WILLIAM MARTIN-DOYLE, JASON A. HANKO, ISABEL KALOFONOS, DIMITRIS KALOFONOS
Format Patent
LanguagePortuguese
Published 10.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.
Bibliography:Application Number: BR2009PI16889