VARIANTE DE FENILANINA AMÔNIA-LIASE PROCARIÓTICA, COMPOSIÇÃO FARMACÊUTICA, MÉTODO PARA O TRATAMENTO DE UMA DOENÇA, USO DE UMA VARIANTE DE FENILALANINA AMÔNIA-LIASE PROCARIÓTICA, MÉTODO PARA O TRATAMENTO DE UMA CONDIÇÃO, E, VARIANTE DE FENILALANINA AMÔNIA-LIASE DE ANABAENA VARIABILIS

The invention provides a prokaryotic phenylalanine ammonia-lyase (PAL) variant, wherein said PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL as well as a pharmaceutical composition comprising same. Further provided is the use...

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Bibliographic Details
Main Authors PAUL A. FITZPATRICK, DANIEL J. WENDT, MICHEL C. VELLARD, EMIL D. KAKKIS
Format Patent
LanguagePortuguese
Published 07.10.2014
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides a prokaryotic phenylalanine ammonia-lyase (PAL) variant, wherein said PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL as well as a pharmaceutical composition comprising same. Further provided is the use of the PAL variant for treating a disease in a subject caused all or in part by a deficiency in phenylalanine hydroxylase (PAH), for treating classic severe PKU in a subject or an infant of between 0 and 3 years having PKU, or for treating a pregnant female having hyperphenylalaninemia (HPA), wherein the PAL variant is administered in combination with a protein-restricted diet.
Bibliography:Application Number: BR2008PI11267