INIBIDORES DE PIM CINASE E MÉTODOS DE SEU USO

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine...

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Main Authors CORNELIA BELLAMACINA, WOOSCOK HAN, PABLO GARCIA, MIKA LINDVALL, JIONG LAN, WILLIAM ANTONIOS-MCCREA, TATIANA ZAVOROTINSKAYA, KAY HUH, MATTHEW BURGER, CYNTHIA SHAFER, CHRISTOPHER MCBRIDE, GISELE NISHIGUCHI, GORDANA ATALLAH, ANNETTE WALTER
Format Patent
LanguagePortuguese
Published 19.08.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
Bibliography:Application Number: BR2008PI08523