PROCESSO DE SÍNTESE DA N-[3-[(2-METÓXI FENIL) SULFANIL] -2-METIL PROPIL]- 3,4-DI-HIDRO -2H-1,5-BENZOXATIEPIN -3-AMINA

Preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine (I) comprises condensation of 7,8-dihydro-6H-5-oxa-9-thia-benzocyclohepten-7-ylamine compound (II) and 5-methoxy-6-(2-methyl-butylsulfanyl)-cyclohexa-1,3-diene compound (III). Preparation of N-[...

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Bibliographic Details
Main Authors BERNARD VACHER, JEAN-LOUIS MAUREL, YVES BRUNEL
Format Patent
LanguagePortuguese
Published 07.01.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine (I) comprises condensation of 7,8-dihydro-6H-5-oxa-9-thia-benzocyclohepten-7-ylamine compound (II) and 5-methoxy-6-(2-methyl-butylsulfanyl)-cyclohexa-1,3-diene compound (III). Preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine (I) comprises condensation of intermediate of 7,8-dihydro-6H-5-oxa-9-thia-benzocyclohepten-7-ylamine compound (II) and 5-methoxy-6-(2-methyl-butylsulfanyl)-cyclohexa-1,3-diene compound of formula (III). R : methyl group, preferably 4-methylphenyl. An independent claim is included for the new intermediate compound (III). [Image] ACTIVITY : Antianginal; Cardiant. MECHANISM OF ACTION : None given. No biological data given.
Bibliography:Application Number: BR2007PI18702