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The present invention is directed to aspartic protease inhibitors represented by the following structural formula: or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I...

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Main Authors ZHENRONG XU, PATRICK T. FLAHERTY, SURESH B. SINGH, SALVACION CACATIAN, ROBERT D. SIMPSON, WEI ZHAO, LANQI JIA, JING YUAN, ALEXEY V. ISHCHENKO, LAWRENCE W. DILLARD, DAVID A. CLAREMON, JOHN J. BALDWIN, COLIN M. TICE, GERARD MCGEEHAN
Format Patent
LanguagePortuguese
Published 03.12.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to aspartic protease inhibitors represented by the following structural formula: or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I). Methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using these aspartic protease inhibitors are also disclosed.
Bibliography:Application Number: BR2007PI18460