COMPOSTOS INIBIDORES DE MTP DE ÁCIDO TETRA-HIDRO-NAFTALENO-1-CARBOXÍLICO SUBSTITUÍDO COM PIPERIDINA OU PIPERAZINA

The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharma...

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Main Authors LIEVEN MEERPOEL, MARCEL VIELLEVOYE, GUUSKE FREDERIKE BUSSCHER, JOANNES THEODORUS MARIA LINDERS, LIBUSE JAROSKOVA, LEO JACOBUS JOZEF BACKX, DIDIER JEAN-CLAUDE BERTHELOT
Format Patent
LanguagePortuguese
Published 22.10.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
Bibliography:Application Number: BR2007PI17357