COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, COMPOSIÇÃO FARMACÊUTICA EMBALADA, MÉTODO DE TRATAR UM PACIENTE QUE APRESENTE UMA DOENÇA RESPONSIVA À INIBIÇÃO DA ATIVIDADE BTK, MÉTODO DE TRATAR UM PACIENTE QUE APRESENTE UMA DOENÇA ESCOLHIDA DENTRE CÂNCER, DOENÇAS AUTOIMUNES, REAÇÕES INFLAMATÓRIAS AGUDAS E TRANSTORNOS ALÉRGICOS, MÉTODO DE AUMENTAR A SENSIBILIDADE DE CÉLULAS CANCEROSAS À QUIMIOTERAPIA, MÉTODO DE REDUZIR O ERRO DE MEDICAÇÃO E MELHORAR O CUMPRIMENTO TERAPÊUTICO DE UM PACIENTE SENDO TRATADO PARA U

At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof is described herein. Pharmaceutical compositions comprising at least one chemical entity of the invention, together with a...

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Bibliographic Details
Main Authors SCOTT A. MITCHELL, JAMES W. DARROW, JEFFREY E. KROPF, SEUNG H. LEE, JIANJUN XU, AARON C. SCHMITT, PETER A. BLOMGREN, KEVIN S. CURRIE
Format Patent
LanguagePortuguese
Published 05.11.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof is described herein. Pharmaceutical compositions comprising at least one chemical entity of the invention, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.
Bibliography:Application Number: BR2007PI16918