derivados de terfenila para o tratamento de doença de alzheimer

• Main Authors: JEREMY MAJOR, MIHIRO SUNOSE, SVENJA BURCKHARDT, CYRILLE BOUSSARD, VALERIE READER, YAN ZHANG, REMEDIOS HERNADEZ-PERNI, ALISON JONES, KATHRYN BELL, FRANCIS WILSON, JESS TAYLOR, RICHARD JOHN HARRISON, CHIH YUNG HO, ADELINE MOREL, ANDREW CANSFIELD
• Format: Patent
• Language: Portuguese
• Published: 23.08.2011
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

DERIVADOS DE TERFENILA PARA O TRATAMENTO DE DOENçA DE ALZHEIMER.A presente invenção refere-se a compostos tendo a fórmula geral (I) com as definições de X, Y, R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 9~, R~ 10~ fornecidas abaixo, e solvatos, hidratos, ésteres, e sais farmaceuticamente aceitáveis destes. Além disso, a invenção refere-se à utilização dos referidos compostos para o tratamento de doença de Alzheimer e sua utilização para a modulação de atividade de -secretase. The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R 1 -R 4 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ³-secretase activity.