compostos de benzimidazola-carboxamida como agonistas do receptor 5-ht4

• Main Authors: Roland Gendron, PAUL ROSS FATHEREE, DANIEL D. LONG, SEAN M. DALZIEL, Seok-Ki Choi, Daniel Marquess, KIRSTEN M. PHIZACKERLEY, LAN JIANG, Robert Murray Mckinnell
• Format: Patent
• Language: Portuguese
• Published: 25.05.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

compostos de benzimidazola-carboxamida como agonistas do receptor 5-ht4. a invenção se refere a compostos agonistas do receptor 5-ht4 de benzimidazola-carboxamida de fõrmula (i): (i) em que r1 e x são conforme definido na especificação ou um sal ou solvato ou estereoisômero farmaceuticamente aceitável dos mesmos. a invenção também se refere à composições farmacêuticas compreendendo tais compostos, métodos de uso de tais compostos para tratar doenças associadas à atividade do receptor 5-ht4 e processos e intermediários úteis para preparo de tais compostos. a invenção ainda se refere à formas cristalinas de um composto de fórmula (i). The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I)wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.