formas farmacêuticas sólidas de cloridrato de oxicodona resistentes ao rompimento com liberação sustentada

• Main Authors: Bartholomaus, Johannes, Arkenau-Maric, Elizabeth, Ashworth, Judy
• Format: Patent
• Language: Portuguese
• Published: 17.09.2019
• Subjects: AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR; SHAPING OR JOINING OF PLASTICS; TRANSPORTING; WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL

formas farmacêuticas resistentes ao rompimento com liberação sustentada. a invenção refere-se a uma forma farmacêutica que compreende uma substância fisiologicamente eficaz (a) com liberação pelo menos parcialmente sustentada, conforme o caso, um ou vários adjuvantes (b) fisiologicamente compatíveis e um polímero sintético ou natural (e), apresentando a forma farmacêutica uma resistência ao rompimento de pelo menos 400 n. Administration form (I) comprises a physiologically effective substance (A); one/more optionally auxiliary materials (B); synthetic or natural polymer (C); and optionally natural, semi-synthetic, or synthetic wax (D) (where (I) exhibits a breaking strength of at least 400 N and under physiological conditions the release of (A) is at least partially retarded). An independent claim is included for the preparation of (I). ACTIVITY : Gastrointestinal-Gen; Metabolic; Antianemic; Cardiovascular-Gen; Dermatological; Uropathic; Endocrine-Gen; Cytostatic; Immunomodulator; Muscular-Gen; Osteopathic; Neuroprotective; Antiparasitic; Insecticide; Respiratory-Gen; Anorectic.