fabricação de enzimas lisossomais altamente fosforiladas e uso das mesmas

• Main Authors: TODD ZANKEL, EMIL D. KAKKIS
• Format: Patent
• Language: Portuguese
• Published: 10.07.2007
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

FABRICAçãO DE ENZIMAS LISOSSOMAIS ALTAMENTE FOSFORILADAS E USO DAS MESMAS Esta invenção fornece composições de enzimas lisossomais altamente fosforiladas, suas composições farmacêuticas, métodos de produzir e purificar tais compostos e composições e seus usos no diagnóestico, profilaxia ou tratamento de doenças e condições, incluindo particularmente doenças de armazenamento lisossomal. This invention provides compositions of highly phosphorylated lysosomal enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases.