stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis

• Main Authors: Amedea Barozzi Seabra, Alexander Marra Moreira, Maíra Martins de Souza Godoy Simões, Spero Penha Morato, Marcelo Ganzarolli de Oliveira
• Format: Patent
• Language: Portuguese
• Published: 22.12.2020
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

"stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis". a presente invenção se refere a um dispositivo para implante intracoronário, introduzindo novos stents eluidores de s-nitrosotióis revestidos com multicamadas de polímeros hidrofílicos, utilizado em procedimentos médicos e se refere aos processos de revestimento de stents com polímeros hidrofílicos contendo s-nitrosotióis incorporados. os stents revestidos com polímeros hidrofílicos contendo s-nitrosotióis são capazes de liberar localmente tanto o óxido nítrico como os próprios s-nitrosotióis, por difusão para aplicações em angioplastia coronária, com o objetivo de inibir a reestenose aguda e crônica. os polímeros hidrofílicos utilizados nos revestimentos são poli (álcool vinílico), poli(vinil pirrolidona) blendas de poli(álcool vinílico)/poli(vinil pirrolidona), poli(álcool vinílico)/poli(etileno glicol), poli(vinil pirrolidona)/poli(etileno glicol) e poli(álcool vinílico)/poli(vinil pirrolidona)/poli(etileno glicol). os processos de revestimento incluem processos de imersão dos stents nas soluções poliméricas contendo os s-nitrosotióis e processos de nebulização das soluções poliméricas contendo os s-nitrosotióis sobre a superfície dos stents. This invention relates to stents coated with hydrophilic polymers containing S-nitrosothiols, which are able to provide local delivery of both nitric oxide and S-nitrosothiols by diffusion. This device is intended for coronary angioplasty applications with the purpose of inhibiting acute and chronic restenosis and refers to processes of stent coating with hydrophilic polymers containing incorporated S-nitrosothiols. This invention refers to an intracoronary implant device used in medical procedures, and introduces new S nitrosothiol-eluting stents coated with hydrophilic polymer multilayers. The hydrophilic polymers used for coating are polyvinyl alcohol, polyvinylpirrolidone and polyvinyl alcohol/polyvinylpirrolidone, polyvinyl alcohol/polyethylene glycol, polyvinylpirrolidone/polyethylene glycol and polyvinyl alcohol/polyvinylpirrolidone/polyethylene glycol blends. The S-nitrosothiols incorporated to the polymer coatings are mainly primary S-nitrosothiols, characterized by the fact of the nitric oxide (NO) molecule being covalently bound to a sulfur (S) atom which, in turn, is linked to a primary carbon in the molecule's structure, thus constituting the S-NO chemical group. The coating processes include immersion of the stents in polymer solutions containing S-nitrosothiols and nebulization processes of the polymer solutions containing S-nitrosothiols onto the stent surface.