processos e intermediários para preparar compostos anticancerígenos

• Main Authors: Richard Shelton Lehner, Timothy Norris, Dinos Paul Santafianos
• Format: Patent
• Language: Portuguese
• Published: 25.05.2021
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS THEREFOR; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FERROUS OR NON-FERROUS ALLOYS; FISHING; FORESTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PRETREATMENT OF RAW MATERIALS; PRODUCTION AND REFINING OF METALS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING; TREATMENT OF ALLOYS OR NON-FERROUS METALS

patente de invenção: "processos e intermediários para preparar compostos anticancerígenos". a presente invenção refere-se a métodos e intermediários para preparação de compostos de fórmula 1 e os sais farmaceuticamente aceitáveis e solvatos resultantes, bem como a compostos estruturalmente relacionados, em que r¹, r² e r^ 15^ são como aqui definidos. os compostos precedentes são úteis no tratamento de distúrbios hiperproliferativas, tais como cânceres, em mamíferos. The present invention relates to methods and intermediates for preparing compounds of the formula 1 and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R , R and R are as defined herein. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals. The present invention also relates to a method of preparing compounds of the formula 9 and the pharmaceutically acceptable salts and solvates thereof, wherein R -R and R are as defined herein.