Composto uso do composto formulação farmacêutica intermediário e processos para a preparação de um composto e de intermediário e para tratamento de uma condição em que existe uma vantagem em inibir a produção de no a partir de l-arginina pela ação de no sintase

• Main Authors: RICHARD GRAHAM KNOWLES, RICHARD MARTIN JOHN PALMER, PATRICIA IFEYINWA DAVIES, HELEN ALICE REBECCA CLARK, HAROLD FRANCIS HODSON, BARRY GEORGE SHEARER, STEVEN SMITH, KARL WITOLD FRANZMANN, DAVID ALAN SAWYER, MARTIN JAMES DRYSDALE
• Format: Patent
• Language: Portuguese
• Published: 05.08.1997
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an intermediate of formula (VI) or a protected derivative thereof, wherein Q is hydrogen or a carboxyl protecting group and Q' is a protecting group. Such intermediates are useful for the preparation of amidino sulphone derivatives which, in turn, have use as selective inhibitors of inducible nitric oxide synthase.