Composiçáo bioativa

An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and polymer are essentially dissolved in the sol...

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Bibliographic Details
Main Authors RAMACHANDRAN CHANDRASEKHARAN, ARTHUR H. GOLDBERG, GORDON L. AMIDON
Format Patent
LanguagePortuguese
Published 21.06.1994
Edition5
Subjects
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Summary:An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and polymer are essentially dissolved in the solvent system to form a sprayable composition having a viscosity of less than 350 cP. Upon dilution with water, the viscosity of the composition increases to in excess of 1000 cP to produce a retentive coating at the site of application which provides enhanced bioavailability of the agent.
Bibliography:Application Number: BR19929205313