forma cristalina ii de bimatoproposta e processo para a preparação da mesma

a presente invenção refere-se a um processo para a preparação de uma forma cristalina de ponto de fusão elevado de bimatoprosta da fórmula (ib). . The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked w...

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Main Authors ZOLTÁN BISCHOF, GÁBOR HAVASI, IRÉN HORTOBÁGYI, ISTVÁN LÁSZLOFI, ZSUZSANNA KARDOS, TIBOR KISS, ADÁM BÓDIS
Format Patent
LanguagePortuguese
Published 10.08.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:a presente invenção refere-se a um processo para a preparação de uma forma cristalina de ponto de fusão elevado de bimatoprosta da fórmula (ib). . The subject of the invention is process for the preparation of the prostaglandin amides of the general formula I, where in the formula the bonds marked with dotted lines may be single or double bonds, in the case of double bounds at positions 5,6 and 13,14 they may be in cis or in trans orientation, Q stands for a hydroxyl-group and Z stands for a hydroxyl- or oxo-group, R1 and R2 independently represent hydrogen atom or a straight or branched C1-10 alkyl- or aralkyl-group, optionally substituted with -ONO2 group, or an aralkyl- or aryl-group, which contains heteroatom, R3 represents a straight or branched, saturated or unsaturated C4-6 hydrocarbon group, or a C4-10 alkylcycloalkyl- or cycloalkyl-group, or an optionally with alkyl group or halogen atom substituted phenyl-, C7-10 alkylaryl- or hetaryl-group, Y represents (CH2)n group or O atom or S atom, and where n=0-3.
Bibliography:Application Number: BR20211208918