Anticorpos anti-p-selectina, molécula de ácido nucléico, vetor, e composição

• Main Authors: KLING DOROTHEE, STERN ANNE, MARTINE VAN VUGT, GRAUS YVO, REBERS FRANK, STREIN PAMELA, HIMBER JACQUES, JAN VAN DE WINKEL, JANSEN-MOLENAAR MIRANDA, PARREN PAUL, STEINER BEAT
• Format: Patent
• Language: Portuguese
• Published: 26.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

a presente invenção refere-se a anticorpos anti-p selectina e, em particular, a anticorpos anti-p selectina e variantes dos mesmos que contêm uma parte fc derivada de origem humana e não se ligam ao fator de complemento c1q. esses anticorpos têm propriedades novas e inventivas, causando um benefício para um paciente que sofre de isquemia crítica de membros ou doença oclusiva de artérias periféricas (cli/paod). This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).