PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1-IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6-METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA

• Main Authors: NICOLAS CUNIERE, NGOC DUC TRAN, XAVIER JEAN-MARIE JUSSEAU, HELEN Y. LUO, RAMDANE RAHMANI, SÉBASTIEN FRANÇOIS EMMANUEL LEMAIRE, CHRISTOPHER ROBERT JAMISON, CYRIL BEN HAIM, SIMON ALBERT WAGSCHAL, CAROLYN S. WEI, BJÖRN SCHMALZBAUER, AMARJIT SINGH, LUCA ALESSANDRO PEREGO, SUBHA MUKHERJEE, DIEGO FERNANDO DOMENICO BROGGINI, CHRIS SFOUGGATAKIS, BIN ZHENG, DUY CHI TRUNG CAO, PHILIPP KOSCHKER, WILLIAM P. GALLAGHER, KOSTIANTYN CHERNICHENKO, SERGEI KOLOTUCHIN, DIMITRI SKLIAR, STEVEN R. WISNIEWSKI, MARTIN D. EASTGATE, ADRIAN ORTIZ, KARL REUTER, ALEXANDER ZHDANKO, MATTHEW PENFIELD MOWER, KIRAN MATCHA, CHRISTOS XIOURAS
• Format: Patent
• Language: Portuguese
• Published: 09.05.2023
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

PROCESSO PARA A FABRICAÇÃO DE (6R,10S)-10-{4-[5-CLORO-2-(4-CLORO-1H-1,2,3-TRIAZOL-1- IL)FENIL]-6-OXO-1(6H)-PIRIMIDINIL}-1-(DIFLUOROMETIL)-6- METIL-1,4,7,8,9,10-HEXAIDRO-11,15-(METENO)PIRAZOLO[4,3-B] [1,7]DIAZACICLOTETRADECIN-5(6H)-ONA. A presente invenção refere-se a diversos processos para a preparação de (6R,10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexaidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6H)-ona: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).