CÉLULAS-TRONCO MESENQUIMAIS QUE COEXPRESSAM CXCR4 E IL-10 E USOS DAS MESMAS

• Main Authors: MARIANO GARCÍA-ARRANZ, MIRIAM HERNANDO RODRÍGUEZ, MERCEDES LÓPEZ SANTALLA, ROSARIO HERVÁS-SALCEDO, JUAN ANTONIO BUEREN RONCERO, MARINA INMACULADA GARIN FERREIRA, DAMIÁN GARCÍA-OLMO, ROSA MARÍA YÁÑEZ GONZÁLEZ, MARÍA FERNÁNDEZ GARCÍA
• Format: Patent
• Language: Portuguese
• Published: 09.05.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

CÉLULAS-TRONCO MESENQUIMAIS QUE COEXPRESSAM CXCR4 E IL-10 E USOS DAS MESMAS. A presente invenção refere-se a células-tronco mesenquimais (MSCs) caracterizadas por serem transduzidas com um vetor de expressão integrativo para coexpressar de forma estável o receptor de quimiocina de tipo 4 CXCR4 e a interleucina IL-10. A presente invenção refere-se também ao uso das ditas MSCs como um medicamento, particularmente no tratamento de doenças inflamatórias e/ou autoimunes. The present invention refers to mesenchymal stem cells (MSCs) characterized in that they are transduced with an integrative expression vector in order to stably co-express the chemokine receptor type 4 CXCR4 and the interleukin IL-10. The present invention also refers to the use of said MSCs as a medicament, particularly in the treatment of inflammatory and/or autoimmune diseases.