FORMAS CRISTALINAS DE UM INIBIDOR DE O-GLICOPROTEÍNA-2-ACETAMIDO-2-DESÓXI-3-D-GLUCOPIRANOSIDASE

• Main Authors: AIREAL DIANE JENKINS, TAE KIM CORREIA, CHAOMIN LI, ASMEROM WELDEAB, YIQING LIN
• Format: Patent
• Language: Portuguese
• Published: 02.05.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

FORMAS CRISTALINAS DE UM INIBIDOR DE O-GLICOPROTEÍNA-2-ACETAMIDO-2-DESÓXI-3-DGLUCOPIRANOSIDASE. A presente invenção refere-se a formas sólidas de N-(4-fluoro-5-((2S,4R)-4-((6-metoxipirimidin-4-il) óxi)-2-metilpirrolidin-1-il) metil) tiazol-2-il) acetamida, composto (I): (I) e o processo de produção das referidas formas sólidas do composto (I). A presente invenção se refere ainda a uma composição farmacêutica compreendendo a Forma B cristalina e a Forma B do composto (I) e métodos de utilização da referida forma e composição farmacêutica no tratamento e prevenção da doença de Alzheimer e distúrbios neurológicos relacionados. Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-46-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-1-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comprising crystalline Form A and Form B of compound (I), and methods of using said form and pharmaceutical composition in the treatment and prevention of Alzheimer's disease and related neurological disorders.