Derivados de quinazolin-4-ona úteis para o tratamento de doenças e distúrbios associados a braf

• Main Authors: BRADLEY JON NEWHOUSE, ELLEN RUTH LAIRD, TARLTON EUGENE, ERIK JAMES HICKEN, DAVID AUSTIN MORENO, PATRICK MICHAEL BARBOUR, BRETT JOSEPH PRIGARO, KATIE KEATON BROWN, REN LI, ADAM WADE COOK, DEAN RUSSELL KAHN, ANDREW TERRANCE METCALF, SPENCER PHILLIP PAJK
• Format: Patent
• Language: Portuguese
• Published: 25.01.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

derivados de quinazolin-4-ona úteis para o tratamento de doenças e distúrbios associados a braf. a presente invenção refere-se a compostos da fórmula i: e sais farmaceuticamente aceitáveis, solvatos e polimorfos do mesmo, em que l, x1, r1, r2, r3, r4, r5 e r6 são como aqui definidos, para o tratamento de doenças e distúrbios associados a braf, incluindo tumores associados a braf, incluindo tumores associados a braf malígnos e benígnos do cns e tumores associados a braf extracranianos malígnos. Provided herein are compounds of the Formula I:and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.