formas polimórficas de dasatinibe

• Main Authors: VIJAYBHASKAR REDDY REGALLA, JITHENDRABABU RAGHUNADHACHETTY, MARIAPPAN KALIAPPAN, VENKATA RAGHAVENDRACHARYULU PALLE, RAMAKRISHNA PARAMESHWAR BHAT
• Format: Patent
• Language: Portuguese
• Published: 14.07.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

a presente invenção fornece co-cristal de dasatinibe-timina e o co-cristal de dasatinibe-adenina. a presente invenção fornece ainda solvato de dasatinibe-butanodiol. a presente invenção fornece ainda dasatinibe-(±)-1,2-butanodiol, dasatinibe (r)-1,2-butanodiol, dasatinibe cristalino (s)-1,2-butanodiol e dasatinibe cristalino (±) - 2, 3-butanodiol e processos para a sua preparação. a presente invenção também fornece um processo para a preparação de dasatinibe amorfo usando solvato de dasatinibe-butanodiol. a presente invenção fornece ainda a preparação de dasatinibe anidro. a presente invenção também fornece um processo para a preparação de dasatinibe monohidratado a partir de dasatinibe anidro. The present invention provides for the dasatinib-thymine co-crystal and dasatinib-adenine co-crystal. The present invention further provides dasatinib-butanediol solvate. The present invention further provides for crystalline dasatinib-(±)-1, 2-Butanediol, crystalline dasatinib (R)-1, 2-Butanediol, crystalline dasatinib (S)-1, 2-Butanediol and crystalline dasatinib (±)-2, 3-Butanediol and processes for preparation thereof. The present invention also provides for a process for preparation of amorphous dasatinib using dasatinib-butanediol solvate. The present invention further provides for the preparation of anhydrous dasatinib. The present invention also provides for a process for preparation of dasatinib monohydrate from anhydrous dasatinib.