derivados de n-(piridin-2-il)piridina-sulfonamida e seu uso no tratamento de doença

• Main Authors: BAOGEN WU, CASEY JACOB NELSON MATHISON, DEAN PAUL PHILLIPS, SEJAL PATEL, ROBERT EPPLE, RODRIGO A. RODRIGUEZ, BEI CHEN, XUEFENG ZHU, AYAKO HONDA, PHILIP LAM, HASNAIN AHMED MALIK, MIHAI AZIMIOARA, VICTOR IVANOVICH NIKULIN, TRUC NGOC NGUYEN
• Format: Patent
• Language: Portuguese
• Published: 18.06.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

a invenção refere-se a compostos heterocíclicos da fórmula (i) em que todas as variáveis são conforme definidas no relatório descritivo; capazes de modular a atividade de cftr. a invenção fornece adicionalmente um método para fabricar compostos da invenção, e seus usos terapêuticos. a invenção fornece adicionalmente métodos para sua preparação, para seu uso médico, em particular, para seu uso no tratamento e gerenciamento de doenças ou distúrbios incluindo fibrose cística e distúrbios relacionados. The invention relates to heterocyclic compounds of the formula (I)in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.