anticorpos humanizados contra a ceacam1

• Main Authors: RONA ORTENBERG, JACOB SCHACHTER, TIMOTHY DAVID JONES, GAL MARKEL, ILANA MANDEL, YAIR SAPIR, ROBERT GEORGE E. HOLGATE, TEHILA BEN-MOSHE, FRANCIS JOSEPH CARR
• Format: Patent
• Language: Portuguese
• Published: 24.10.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

a presente invenção se refere a anticorpos humanizados, aptos a formar uma liga-ção específica com as moléculas da ceacam1 humana contendo mutações rever-sas humano-murino em regiões variáveis não cdr, e às suas sequências codifica-doras de polinucleotídeo. também são fornecidas composições farmacêuticas con-tendo tais anticorpos, bem como métodos para seu uso no tratamento e no diagnós-tico do câncer e demais condições. Humanized antibodies, capable of specific binding to human CEACAM1 molecules containing back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising said antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.